Abstract | OBJECTIVE: METHODS: Multiple variable logistic regression and other statistical analyses of data relating to 1733 fetuses from 1703 pregnancies (147 of which were not exposed to antiepileptic drugs during pregnancy). RESULTS: CONCLUSIONS: The valproate findings are mostly in keeping with the published literature, but the topiramate finding regarding hypospadias and the association between CBZ exposure and various renal tract abnormalities raise questions of organ specific teratogenesis. More extensive data are desirable, particularly in relation to topiramate, which is being used increasingly as a migraine prophylactic in women of childbearing potential.
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Authors | F J E Vajda, T J O'Brien, J Graham, C M Lander, M J Eadie |
Journal | Acta neurologica Scandinavica
(Acta Neurol Scand)
Vol. 128
Issue 4
Pg. 228-34
(Oct 2013)
ISSN: 1600-0404 [Electronic] Denmark |
PMID | 23461556
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons A/S. |
Chemical References |
- Anticonvulsants
- Topiramate
- Fructose
- Valproic Acid
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Topics |
- Abnormalities, Drug-Induced
(epidemiology, etiology)
- Anticonvulsants
(adverse effects)
- Australia
(epidemiology)
- Epilepsy
(drug therapy)
- Female
- Fetal Diseases
(chemically induced)
- Fructose
(adverse effects, analogs & derivatives)
- Humans
- Male
- Pregnancy
- Pregnancy Complications
(chemically induced, epidemiology)
- Prenatal Exposure Delayed Effects
(chemically induced, epidemiology)
- Regression Analysis
- Risk Factors
- Topiramate
- Valproic Acid
(adverse effects)
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