Melanosis coli--histochemical and immunohistochemical comparison of the pigments of melanosis coli and Dubin-Johnson syndrome.

Abstract

We compared the pigment of melanosis coli with the pigment of Dubin-Johnson syndrome, melanin, and lipofuscin. The pigment of melanosis coli appeared similar to lipofuscin in that it stained positively with periodic acid-Schiff, oil red-0 and Victoria blue stains and revealed negative reactions to the immunohistochemical stains for S-100 protein and neuron specific enolase, but had similarity to melanin as shown by the positive reaction to Fontana-Masson stain and negative autofluorescence. The pigment of Dubin-Johnson syndrome showed the same histochemical and immunohistochemical characteristics as that of melanosis coli. The results indicate that the pigments of melanosis coli and Dubin-Johnson syndrome are identical and are variants of lipofuscin.

• Authors: C Park, N H Cho, H J Jeong
• Journal: Yonsei medical journal (Yonsei Med J) Vol. 31 Issue 1 Pg. 27-32 (Mar 1990) ISSN: 0513-5796 [Print] Korea (South)
• PMID: 2346038 (Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pigments, Biological

Topics

• Colonic Diseases (metabolism)
• Histocytochemistry
• Humans
• Immunohistochemistry
• Jaundice, Chronic Idiopathic (metabolism)
• Male
• Melanosis (metabolism)
• Middle Aged
• Pigments, Biological (metabolism)