[Clinical problems in medical mycology: Problem number 47].

Abstract

A 66 year-old man, who had lived in Paraguay and was a rural worker, was admitted to Infectious Diseases Hospital F. J. Muñiz in Buenos Aires. He presented fever, loss of body weight, cough, mucopurulent expectoration, wide perianal ulceration, paresthesia and paresis of both legs as well as vesical and anal sphincter dysfunction. He was a heavy smoker and drinker. Thorax X-ray examination showed bilateral micronodular interstitial lesions. With a NMR of the dorsolumbar spine region a nodular lesion outside the spinal cord (which produced compression of this organ) was shown. The diagnosis of disseminated paracoccidiodomycosis was based on the finding of Paracoccidioides brasiliensis in the skin ulcer in histopathology and mycology studies, and on the positive results of serologic tests with paracoccidioidin antigen. The patient was treated with trimethoprim-sulfamethoxazole with good clinical outcome.

• Authors: Marcelo Corti, Estela Muzzio, María Florencia Villafañe, María Marta Priarone, Fernando Messina, Alicia Arechavala, Elena Maiolo, Ricardo Negroni, Oscar Franze
• Journal: Revista iberoamericana de micologia (Rev Iberoam Micol) 2013 Jul-Sep Vol. 30 Issue 3 Pg. 213-5 ISSN: 2173-9188 [Electronic] Spain
• Vernacular Title: Problemas clínicos en micología médica: problema número 47.
• PMID: 23454255 (Publication Type: Case Reports, Clinical Conference, Journal Article)
• Copyright: Copyright © 2013 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

Chemical References

• Anti-Infective Agents
• Antibodies, Fungal
• Fungal Proteins
• paracoccidioidin
• Trimethoprim, Sulfamethoxazole Drug Combination

Topics

• Agricultural Workers' Diseases (diagnosis, microbiology)
• Anti-Infective Agents (therapeutic use)
• Antibodies, Fungal (blood)
• Fungal Proteins (immunology)
• Fungemia (diagnosis, drug therapy, microbiology)
• Humans
• Lung Diseases, Fungal (diagnostic imaging, microbiology)
• Male
• Middle Aged
• Paracoccidioides (isolation & purification)
• Paracoccidioidomycosis (complications, diagnosis, drug therapy, microbiology)
• Paresthesia (etiology)
• Skin Ulcer (microbiology)
• Spinal Cord Compression (etiology)
• Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)