The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis.

Abstract

BACKGROUND:

Robenacoxib is a novel and highly selective inhibitor of COX-2 in dogs and cats and because of its acidic nature is regarded as being tissue-selective. Thirty four dogs with stifle osteoarthritis secondary to failure of the cranial cruciate ligament were recruited into this study. Lameness, radiographic features, synovial cytology and C-reactive protein concentrations in serum and synovial fluid were assessed before and 28 days after commencing a course of Robenacoxib at a dose of 1 mg/kg SID.

RESULTS:

There was a significant reduction in the lameness score (P < 0.01) and an increase in the radiographic score (P < 0.05) between pre- and post-treatment assessments. There was no difference between pre- (median 1.49 mg/l; Q1-Q3 0.56-4.24 mg/L) and post - (1.10 mg/L; 0.31-1.78 mg/L) treatment serum C-reactive protein levels although synovial fluid levels were significantly reduced (pre- : 0.44 mg/L; 0.23-1.62 mg/L; post- : 0.17 mg/L; 0.05-0.49 mg/L) (P < 0.05). There was no correlation between C-reactive protein concentrations in serum and matched synovial fluid samples.

CONCLUSIONS:

Robenacoxib proved effective in reducing lameness in dogs with failure of the cranial cruciate ligament and osteoarthritis of the stifle joint. The drug also reduced levels of C-reactive protein in the synovial fluid taken from the affected stifle joint. Robenacoxib appears to reduce articular inflammation as assessed by C-reactive protein which supports the concept that Robenacoxib is a tissue-selective non-steroidal anti-inflammatory drug.

• Authors: David Bennett, Peter David Eckersall, Mary Waterston, Veronica Marchetti, Alessandra Rota, Eilidh McCulloch, Silvia Sbrana
• Journal: BMC veterinary research (BMC Vet Res) Vol. 9 Pg. 42 (Mar 01 2013) ISSN: 1746-6148 [Electronic] England
• PMID: 23452411 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclooxygenase Inhibitors
• Phenylacetates
• C-Reactive Protein
• Diphenylamine
• robenacoxib

Topics

• Animals
• C-Reactive Protein (analysis)
• Cyclooxygenase Inhibitors (therapeutic use)
• Diphenylamine (analogs & derivatives, therapeutic use)
• Dog Diseases (diagnostic imaging, drug therapy)
• Dogs
• Female
• Lameness, Animal (diagnostic imaging, drug therapy, etiology)
• Male
• Osteoarthritis (complications, diagnostic imaging, drug therapy, veterinary)
• Phenylacetates (therapeutic use)
• Radiography
• Stifle (diagnostic imaging)
• Synovial Fluid (chemistry, drug effects)