Liposome encapsulated MnCl2 as a liver specific contrast agent for magnetic resonance imaging.

Abstract

We examined the usefulness of MnCl2 entrapped in liposomes as a liver specific contrast agent for magnetic resonance imaging. Toxicity experiments showed that the effective dose for imaging experiments was 7 to 11 times lower than the LD50 of free MnCl2. In rats with implanted liver tumors, liposome encapsulated MnCl2 caused a two- to three-fold increase in the relaxation rate of the liver while having little effect on the relaxation rate of tumor tissue. T1 weighted, magnetic resonance images obtained at 0.5 T of an R3230 adenocarcinoma implanted in the liver showed an increase in the signal intensity of both normal liver and tumor tissue after the injection of free MnCl2 (25 mumole/kg). However, after the injection of liposome encapsulated MnCl2 (40 mumole/kg) the liver exhibited a marked increase in signal intensity with little change in the signal intensity of the tumor tissue. These results suggest that liposome encapsulated MnCl2 has excellent potential as a liver specific contrast agent for the improved detection of liver metastases.

• Authors: M R Niesman, G G Bacic, S M Wright, H J Swartz, R L Magin
• Journal: Investigative radiology (Invest Radiol) Vol. 25 Issue 5 Pg. 545-51 (May 1990) ISSN: 0020-9996 [Print] United States
• PMID: 2345086 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Chlorides
• Contrast Media
• Drug Carriers
• Liposomes
• Manganese Compounds
• Manganese
• manganese chloride

Topics

• Animals
• Chlorides
• Contrast Media (administration & dosage, toxicity)
• Drug Carriers
• Female
• Liposomes
• Liver Neoplasms, Experimental (diagnosis)
• Magnetic Resonance Imaging
• Male
• Manganese (administration & dosage)
• Manganese Compounds
• Manganese Poisoning
• Mice
• Neoplasm Transplantation
• Rats
• Rats, Inbred F344