Abstract | CONTEXT:
Endometriosis is a chronic inflammatory disease in which immune response and production of estrogen in endometriotic tissues are involved in the development of the disease. Prostaglandin E2 ( PGE2) stimulates aromatase ( P450arom) expression in endometrioma stromal cells (ESCs) and increases the production of estrogens. On the other hand, an accumulating amount of evidence suggests that IL-4, a typical Th2 cytokine, plays important roles in the disease. OBJECTIVE: DESIGN, PATIENTS, AND MAIN OUTCOME MEASURES: RESULTS: CONCLUSIONS:
IL-4 in combination with PGE2 may enhance estrogen production in endometriotic tissues, implying an elaborate mechanism that Th2 immune response augments inflammation-dependent progression of the disease.
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Authors | Yoko Urata, Yutaka Osuga, Ikumi Akiyama, Miwako Nagai, Gentaro Izumi, Masashi Takamura, Akiko Hasegawa, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Yoshino, Kaori Koga, Shiro Kozuma |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 98
Issue 4
Pg. 1583-90
(Apr 2013)
ISSN: 1945-7197 [Electronic] United States |
PMID | 23450050
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Small Interfering
- Interleukin-4
- Estrone
- 3 beta-hydroxysteroid dehydrogenase type II
- Progesterone Reductase
- Dinoprostone
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Topics |
- Cells, Cultured
- Dinoprostone
(pharmacology)
- Drug Synergism
- Endometriosis
(enzymology, genetics, metabolism, pathology)
- Estrone
(metabolism)
- Female
- Gene Expression Regulation, Enzymologic
(drug effects)
- Humans
- Interleukin-4
(pharmacology)
- Models, Biological
- Ovarian Diseases
(enzymology, genetics, metabolism, pathology)
- Pregnancy
- Progesterone Reductase
(antagonists & inhibitors, genetics, metabolism)
- RNA, Small Interfering
(pharmacology)
- Stromal Cells
(drug effects, enzymology, metabolism, pathology)
- Up-Regulation
(drug effects)
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