Abstract | OBJECTIVE: MATERIALS AND METHODS: Rats were exposed to either a low-fat diet (LFD; 13.5% fat) or high-fat diet (HFD; 60% fat), and received Det (0.5 U kg(-1)), Glar (0.2 U kg(-1)) or vehicle (Veh) SC once daily for 4 weeks. These dosages of insulin were equipotent in rats with respect to blood-glucose concentration and did not induce hypoglycemia. RESULTS: As predicted by current models of energy homeostasis, neither insulin Det nor Glar therapy affected food intake and weight gain in LFD rats. Det treatment significantly attenuated food intake, body weight gain and fat mass gain relative to the Glar and Veh in high-fat fed animals, mirroring observations in humans. CONCLUSIONS: That neither insulin group gained excess weight, suggests weight gain with SC basal insulin therapy may not be inevitable. Our data further suggest that Det possesses a unique property to attenuate the development of obesity associated with a HFD.
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Authors | J M Rojas, R L Printz, K D Niswender |
Journal | Nutrition & diabetes
(Nutr Diabetes)
Vol. 1
Pg. e10
(Jul 04 2011)
ISSN: 2044-4052 [Electronic] England |
PMID | 23449422
(Publication Type: Journal Article)
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