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[Role of intracellular pH in the development of resistance of leukemic cells to antineoplastic drugs].

Abstract
Intracellular pH (pHi) of mouse lymphoid leukemia P388 cells was measured at the wavelength of 518 and 570 nm of fluorescein: pHi of rubomycin-sensitive P388 cells was higher than pHi of the cells resistant to this antitumour antibiotic (6.98 +/- 0.04 and 6.63 +/- 0.03, respectively, P less than 0.001). The role of pHi is established during induction of the resistance of tumour cells to the antitumour drugs.
AuthorsO L Shestova, T A Ogloblina, L L Litinskaia
JournalEksperimental'naia onkologiia (Eksp Onkol) Vol. 12 Issue 3 Pg. 61-2 ( 1990) ISSN: 0204-3564 [Print] Ukraine
Vernacular TitleRol' vnutrikletochnogo pH v vozniknovenii ustoĭchivosti leĭkoznykh kletok k protivoopukholevym preparatam.
PMID2344828 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Daunorubicin
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Daunorubicin (therapeutic use)
  • Drug Resistance
  • Hydrogen-Ion Concentration
  • Leukemia P388 (drug therapy, metabolism)
  • Leukemia, Experimental (drug therapy)
  • Mice
  • Mice, Inbred Strains

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