Abstract |
Intracellular pH (pHi) of mouse lymphoid leukemia P388 cells was measured at the wavelength of 518 and 570 nm of fluorescein: pHi of rubomycin-sensitive P388 cells was higher than pHi of the cells resistant to this antitumour antibiotic (6.98 +/- 0.04 and 6.63 +/- 0.03, respectively, P less than 0.001). The role of pHi is established during induction of the resistance of tumour cells to the antitumour drugs.
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Authors | O L Shestova, T A Ogloblina, L L Litinskaia |
Journal | Eksperimental'naia onkologiia
(Eksp Onkol)
Vol. 12
Issue 3
Pg. 61-2
( 1990)
ISSN: 0204-3564 [Print] Ukraine |
Vernacular Title | Rol' vnutrikletochnogo pH v vozniknovenii ustoĭchivosti leĭkoznykh kletok k protivoopukholevym preparatam. |
PMID | 2344828
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Daunorubicin
|
Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Daunorubicin
(therapeutic use)
- Drug Resistance
- Hydrogen-Ion Concentration
- Leukemia P388
(drug therapy, metabolism)
- Leukemia, Experimental
(drug therapy)
- Mice
- Mice, Inbred Strains
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