Abstract | BACKGROUND: METHODS: Patients were selected from the French National Reference Center for Staphylococci. We retrospectively compared the clinical characteristics of patients with a generalized rash during Staphylococcus aureus infection. Patients who met the criteria of staphylococcal scalded skin syndrome or toxic shock syndrome were excluded. The patients were classified into 2 groups depending on the presence of a gene coding for exfoliatin or for superantigenic toxin. RESULTS: We included 13 cases with exfoliatin and 9 with superantigens. The patients of the exfoliatin group were more likely to have facial involvement, fold involvement and a superficial focus of infection. In the second group, S. aureus was isolated from a deeper focus in 8 of 9 patients. CONCLUSION: Mild forms of S. aureus toxin-mediated infection affect the pediatric population. Examination made it possible to distinguish an exanthema associated with an exfoliatin from one associated with a superantigen. This early clinical distinction results in differences in management.
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Authors | Johan Courjon, Thomas Hubiche, Alice Phan, Anne Tristan, Michele Bès, François Vandenesch, Jerome Etienne, Pascal Del Giudice, Yves Gillet |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 32
Issue 7
Pg. 727-30
(Jul 2013)
ISSN: 1532-0987 [Electronic] United States |
PMID | 23446443
(Publication Type: Journal Article)
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Chemical References |
- Bacterial Toxins
- Enterotoxins
- Exfoliatins
- Superantigens
- enterotoxin F, Staphylococcal
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Topics |
- Bacterial Toxins
(genetics)
- Child, Preschool
- Clinical Medicine
(methods)
- Diagnosis, Differential
- Enterotoxins
(genetics)
- Exanthema
(etiology, pathology)
- Exfoliatins
(genetics)
- France
- Humans
- Shock, Septic
(microbiology, pathology)
- Staphylococcal Scalded Skin Syndrome
(microbiology, pathology)
- Staphylococcus aureus
(genetics, isolation & purification, pathogenicity)
- Superantigens
(genetics)
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