HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The impact of viral respiratory tract infections on long-term morbidity and mortality following lung transplantation: a retrospective cohort study using a multiplex PCR panel.

AbstractBACKGROUND:
The major factor affecting morbidity and mortality after lung transplantation (LTX) is bronchiolitis obliterans syndrome. Earlier studies have suggested a connection between the presence of viral agents and morbidity in this patient group, but data are somewhat conflicting. The objective of this study was to investigate the development of bronchiolitis obliterans syndrome and graft loss after LTX in relation to the presence of respiratory viruses during the first year after LTX.
METHOD:
The study is a retrospective cohort study of 39 LTX recipients 11Y13 years after surgery. Patients were operated between January 1, 1998 and December 31, 2000 at Sahlgrenska University Hospital. The presence of virus in bronchoalveolar lavage (BAL) fluids from patients during the first year after surgery was analyzed retrospectively using a multiplex polymerase chain reaction test capable of detecting 15 respiratory agents. The time to BOS or graft loss was analyzed in relation to the positive findings in BAL during the first year after LTX.
RESULTS:
Patients with one or more viruses detected in BAL during the first year after transplantation demonstrated a significantly faster development of BOS (P=0.005) compared with patients with no virus detected. No significant difference in graft survival was found.
CONCLUSION:
Our results suggest that the long-term prognosis after LTX may be negatively affected by viral respiratory tract infections during the first year after LTX.
AuthorsJesper Magnusson, Johan Westin, Lars-Magnus Andersson, Robin Brittain-Long, Gerdt C Riise
JournalTransplantation (Transplantation) Vol. 95 Issue 2 Pg. 383-8 (Jan 27 2013) ISSN: 1534-6080 [Electronic] United States
PMID23444472 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Viral
Topics
  • Adult
  • Bronchiolitis Obliterans (mortality, virology)
  • Bronchoalveolar Lavage Fluid (virology)
  • Chi-Square Distribution
  • DNA, Viral (analysis)
  • Disease-Free Survival
  • Female
  • Graft Rejection (mortality, virology)
  • Graft Survival
  • Humans
  • Kaplan-Meier Estimate
  • Lung Transplantation (adverse effects, mortality)
  • Male
  • Middle Aged
  • Multiplex Polymerase Chain Reaction
  • Predictive Value of Tests
  • Prevalence
  • Respiratory Tract Infections (diagnosis, mortality, virology)
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Sweden (epidemiology)
  • Time Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: