Abstract | BACKGROUND AND PURPOSE: PATIENTS AND METHODS: RESULTS: We selected PBT in anticipation of dose reduction to normal tissue. The clinical target volume was defined as the area of the primary tumor and lymph node metastases plus an 8-mm margin. After treatment with 36 GyE (Gray equivalent) in 20 fractions (4-5 fractions per week), dietary intake was decreased by mucositis and intravenous hyperalimentation was started. Termination of treatment for 2.5 weeks was required to relieve mucositis. Administration of 59.4 GyE in 33 fractions markedly reduced the size of the primary tumor, but also caused moderate mucositis that required termination of PBT. One month later, lung metastases and breast cancer developed and the patient died 9 months after PBT. At this time the reduction in size of the primary tumor was maintained without severe late toxicity. CONCLUSION: We obtained almost complete response for a radiosensitive patient with a deficiency of DNA repair, indicating the excellent dose concentration of proton beam therapy.
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Authors | M Mizumoto, H Hashii, M Senarita, S Sakai, T Wada, T Okumura, K Tsuboi, H Sakurai |
Journal | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
(Strahlenther Onkol)
Vol. 189
Issue 4
Pg. 335-8
(Apr 2013)
ISSN: 1439-099X [Electronic] Germany |
PMID | 23443610
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Bloom Syndrome
(radiotherapy)
- Carcinoma, Squamous Cell
(pathology, radiotherapy)
- Dose Fractionation, Radiation
- Female
- Follow-Up Studies
- Humans
- Lymphatic Metastasis
(pathology, radiotherapy)
- Magnetic Resonance Imaging
- Mouth Mucosa
(radiation effects)
- Mucositis
(etiology)
- Neoplasm Staging
- Oropharyngeal Neoplasms
(pathology, radiotherapy)
- Proton Therapy
(adverse effects, methods)
- Radiation Injuries
(etiology)
- Radiotherapy Dosage
- Radiotherapy Planning, Computer-Assisted
(methods)
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