Abstract | BACKGROUND: METHODS: An observational cohort study was performed in 2 chest diseases teaching hospitals. We included all ILD patients with acute respiratory failure admitted between 2008 and 2010. Subject demographics, noninvasive ventilation (NIV) and invasive ventilation use, and mortality were obtained from medical records. Subjects receiving NIV were divided based on their continuous or non-continuous demand for NIV. NIV failure was defined as intubation for invasive ventilation, or death during NIV. Cox regression analysis was used to determine the hazard ratio for NIV failure. RESULTS: We enrolled 120 subjects: 71 male, median age 66 years. The types of ILD were idiopathic pulmonary fibrosis (n = 96), collagen vascular disease (n = 10), silicosis (n = 9), drug induced (n = 3), and eosinophilic pneumonia (n = 2). The median (IQR) Acute Physiology and Chronic Health Evaluation (APACHE II) score was 24 (19-31), and 75 (62.5%) subjects received NIV on ICU admission, 47 (62.7%) of whom needed continuous NIV. The NIV failure rate was 49.3% (n = 37). The mortality rates of continuous NIV, non-continuous NIV, invasive ventilation, and total ICU were 61.7% (29/47), 10.7% (3/28), 89.7% (61/68), 60% (72/120), respectively. APACHE II > 20 and continuous NIV demand indicated significant risk for NIV failure: hazard ratio 2.77 (95% CI 1.19-6.45), P < .02, and 5.12, (1.44-18.19), P < .01, respectively. CONCLUSIONS: Because of higher mortality, physicians should consider invasive ventilation cautiously in the ICU management of ILD patients with acute respiratory failure. NIV may be an option in less severely ill patients with APACHE II score < 20.
|
Authors | Gökay Güngör, Dursun Tatar, Cüneyt Saltürk, Pinar Çimen, Zuhal Karakurt, Cenk Kirakli, Nalan Adıgüzel, Özlem Ediboglu, Huri Yılmaz, Özlem Yazıcıoglu Moçin, Merih Balcı, Adnan Yılmaz |
Journal | Respiratory care
(Respir Care)
Vol. 58
Issue 3
Pg. 525-31
(Mar 2013)
ISSN: 1943-3654 [Electronic] United States |
PMID | 23443285
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
Topics |
- APACHE
- Aged
- Female
- Hospital Mortality
- Humans
- Intensive Care Units
- Lung Diseases, Interstitial
(mortality, therapy)
- Male
- Middle Aged
- Respiration, Artificial
(methods, mortality)
- Retrospective Studies
- Risk Factors
|