Meat-related compounds and colorectal cancer risk by anatomical subsite.

Abstract

Since meat may be involved in the etiology of colorectal cancer, associations between meat-related compounds were examined to elucidate underlying mechanisms in a population-based case-control study. Participants (989 cases/1,033 healthy controls) completed a food frequency questionnaire with a meat-specific module. Multivariable logistic regression was used to examine associations between meat variables and colorectal cancer; polytomous logistic regression was used for subsite-specific analyses. The following significant positive associations were observed for meat-related compounds: 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and colorectal, distal colon, and rectal tumors; 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and colorectal and colon cancer tumors; nitrites/nitrates and proximal colon cancer; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and rectal cancer; and benzo[a]pyrene and rectal cancer (P-trends < 0.05). For analyses by meat type, cooking method, and doneness preference, positive associations between red processed meat and proximal colon cancer and pan-fried red meat and colorectal cancer were found (P-trends < 0.05). Inverse associations were observed between unprocessed poultry and colorectal, colon, proximal colon, and rectal tumors; grilled/barbequed poultry and proximal colon cancer; and well-done/charred poultry and colorectal, colon, and proximal colon tumors (P-trends < 0.05). HCAs, PAHs, nitrites, and nitrates may be involved in colorectal cancer etiology. Further examination into the unexpected inverse associations between poultry and colorectal cancer is warranted.

• Authors: Paige E Miller, Philip Lazarus, Samuel M Lesko, Amanda J Cross, Rashmi Sinha, Jason Laio, Jay Zhu, Gregory Harper, Joshua E Muscat, Terryl J Hartman
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 65 Issue 2 Pg. 202-26 ( 2013) ISSN: 1532-7914 [Electronic] United States
• PMID: 23441608 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Imidazoles
• Nitrates
• Nitrites
• Quinoxalines
• Benzo(a)pyrene
• 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
• 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
• 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine

Topics

• Aged
• Animals
• Benzo(a)pyrene (toxicity)
• Case-Control Studies
• Colonic Neoplasms (etiology)
• Colorectal Neoplasms (epidemiology, etiology)
• Cooking
• Feeding Behavior
• Female
• Humans
• Imidazoles (toxicity)
• Logistic Models
• Male
• Meat (adverse effects)
• Meat Products (adverse effects)
• Middle Aged
• Nitrates (adverse effects)
• Nitrites (adverse effects)
• Pennsylvania (epidemiology)
• Poultry
• Quinoxalines (toxicity)
• Rectal Neoplasms (etiology)
• Risk Factors
• Surveys and Questionnaires