Abstract | BACKGROUND: Diabetes increases the risk of vascular problems by two times compared with a healthy individual, with deposition of fats in blood vessel and this includes cardiovascular disease. The treatment regimens for patients suffering from both diseases generally include prolonged use of anti-diabetic drugs for diabetes and anti-arrhythmic drugs for cardiac arrhythmias. AIM: MATERIALS AND METHODS: The study was conducted in normal rats and diabetic induced rats (with Alloxan monohydrate 100 mg/kg body weight). Albino rats weighing between 160 and 280 g were administered oral doses of Rosiglitazone 0.72 mg/kg, Mexiletine 36 mg/kg, or Disopyramide 18 mg/kg of bodyweight and their combination, with 1 week of washout between treatments. Eighteen rats were divided into three sub-sets with six rats in each sub-set. After 4 days, the blood glucose was estimated to confirm the diabetes. The Analysis of Covariance (ANCOVA) using MedCalc(®) software Version 11.6.1.0 was performed to analyze mean change in blood glucose between treatments with body weight as co-variable and treatment as factor for normal and diabetic rats. RESULTS: CONCLUSION:
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Authors | Ym Mohammed, Ei Mohammed, N Mohiuddin, Ss Syeda |
Journal | Annals of medical and health sciences research
(Ann Med Health Sci Res)
Vol. 2
Issue 2
Pg. 152-6
(Jul 2012)
ISSN: 2141-9248 [Print] India |
PMID | 23440669
(Publication Type: Journal Article)
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