Abstract |
Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.
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Authors | Michael Bukrinsky, Alexander Orekhov, Michael Ditiatkovski, Dmitri Sviridov |
Journal | Current pharmaceutical design
(Curr Pharm Des)
Vol. 19
Issue 33
Pg. 5904-8
( 2013)
ISSN: 1873-4286 [Electronic] United Arab Emirates |
PMID | 23438962
(Publication Type: Journal Article, Review)
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Chemical References |
- Chemotactic Factors
- Cyclosporins
- Basigin
- Matrix Metalloproteinases
- Cyclophilins
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Topics |
- Animals
- Atherosclerosis
(drug therapy, enzymology, immunology)
- Basigin
(immunology)
- Chemotactic Factors
(immunology)
- Cyclophilins
(antagonists & inhibitors, immunology)
- Cyclosporins
(pharmacology, therapeutic use)
- Endothelium, Vascular
(drug effects, immunology)
- Humans
- Matrix Metalloproteinases
(immunology)
- Molecular Targeted Therapy
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