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Cyclophilins in atherosclerosis: a new therapeutic target?

Abstract
Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.
AuthorsMichael Bukrinsky, Alexander Orekhov, Michael Ditiatkovski, Dmitri Sviridov
JournalCurrent pharmaceutical design (Curr Pharm Des) Vol. 19 Issue 33 Pg. 5904-8 ( 2013) ISSN: 1873-4286 [Electronic] United Arab Emirates
PMID23438962 (Publication Type: Journal Article, Review)
Chemical References
  • Chemotactic Factors
  • Cyclosporins
  • Basigin
  • Matrix Metalloproteinases
  • Cyclophilins
Topics
  • Animals
  • Atherosclerosis (drug therapy, enzymology, immunology)
  • Basigin (immunology)
  • Chemotactic Factors (immunology)
  • Cyclophilins (antagonists & inhibitors, immunology)
  • Cyclosporins (pharmacology, therapeutic use)
  • Endothelium, Vascular (drug effects, immunology)
  • Humans
  • Matrix Metalloproteinases (immunology)
  • Molecular Targeted Therapy

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