Association between the methionine synthase A2756G polymorphism and neural tube defect risk: a meta-analysis.

Abstract

Many studies have accessed the association between methionine synthase (MTR) A2756G polymorphism and neural tube defect (NTD). However, the conclusions are inconsistent. Our study aimed to clarify the nature of the genetic risks contributed by this polymorphism for NTD using meta-analysis. We searched electronic literature from the PubMed, EMBASE, and Medline databases, from which 10 articles were selected according to the inclusion criteria. The meta-analysis was conducted in 3 groups, namely, NTD patients, mothers with NTD offspring and fathers with NTD offspring. Pooled odds ratios (ORs) and 95% confidence intervals were used to evaluate the strength of the association and the result was corrected by multiple testing. To sum up, no associations between the MTR A2756G polymorphism and NTD risk were found among the 3 groups in all genetic models. However, as their sample size is not large enough, this result needs further research.

• Authors: Mei Yang, Liping Yang, Ling Qi, Yiyang Guo, Xiaofang Lin, Yu Zhang, Yukai Du
• Journal: Gene (Gene) Vol. 520 Issue 1 Pg. 7-13 (May 10 2013) ISSN: 1879-0038 [Electronic] Netherlands
• PMID: 23438943 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

Topics

• 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (genetics)
• Base Sequence
• Confidence Intervals
• Databases, Genetic
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Male
• Neural Tube Defects (enzymology, genetics)
• Odds Ratio
• Pedigree
• Polymorphism, Genetic