Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial.

We studied the macular pigment ocular density (MPOD) in patients with early age macular degeneration (AMD) before and 1 year after nutritional supplementation with lutein and docosahexaenoic acid (DHA). Forty-four patients with AMD were randomly divided into two groups that received placebo (n = 21) or a nutritional supplement (n = 23, 12 mg of lutein and 280 mg of DHA daily). Heterochromatic flicker photometry was used to determine the MPOD. At baseline, the MPOD in AMD patients with placebo was 0.286 ± 0.017 meanwhile in AMD patients with supplementation it was 0.291 ± 0.016. One year later, the mean MPOD had increased by 0.059 in the placebo group and by 0.162 in patients receiving lutein and DHA. This difference between groups was significant (p < 0.05). Lutein and DHA supplementation is effective in increasing the MPOD and may aid in prevention of age related macular degeneration.
AuthorsAlfredo García-Layana, Sergio Recalde, Angel Salinas Alamán, Patricia Fernández Robredo
JournalNutrients (Nutrients) Vol. 5 Issue 2 Pg. 543-51 (Feb 2013) ISSN: 2072-6643 [Electronic] Switzerland
PMID23434908 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Placebos
  • Retinal Pigments
  • Docosahexaenoic Acids
  • Lutein
  • Aged
  • Dietary Supplements
  • Docosahexaenoic Acids (administration & dosage)
  • Female
  • Humans
  • Lutein (administration & dosage)
  • Macula Lutea (pathology, physiopathology)
  • Macular Degeneration (pathology, physiopathology, prevention & control)
  • Male
  • Photometry
  • Placebos
  • Retinal Pigments
  • Visual Acuity

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