Isolation and structural elucidation of chondrosterins F-H from the marine fungus Chondrostereum sp.

Abstract

The marine fungus Chondrostereum sp. was collected from a soft coral of the species Sarcophyton tortuosum from the South China Sea. Three new compounds, chondrosterins F-H (1, 4 and 5), together with three known compounds, incarnal (2), arthrosporone (3), and (2E)-decene-4,6,8-triyn-1-ol (6), were isolated. Their structures were elucidated primarily based on NMR and MS data. Incarnal (2) exhibited potent cytotoxic activity against various cancer cell lines.

• Authors: Hou-Jin Li, Ting Chen, Ying-Lu Xie, Wen-Dan Chen, Xiao-Feng Zhu, Wen-Jian Lan
• Journal: Marine drugs (Mar Drugs) Vol. 11 Issue 2 Pg. 551-8 (Feb 22 2013) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 23434797 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Sesquiterpenes
• chondrosterin F
• chondrosterin G
• chondrosterin H

Topics

• Animals
• Anthozoa (microbiology)
• Antineoplastic Agents (chemistry)
• Basidiomycota (chemistry, metabolism)
• Cell Line, Tumor
• Humans
• Molecular Structure
• Sesquiterpenes (chemistry)