Abstract | PURPOSE: METHOD: Changes in FRS and metabolic syndrome status were compared between patients with BMI ≥ 27 and non-HDL-C ≥ 130 mg/dL randomly assigned to stay on stable current treatment ( olanzapine, quetiapine, or risperidone) or switch to treatment with aripiprazole with 24 weeks of follow-up. All study participants were enrolled in a behavioral program that promoted healthy diet and exercise. RESULTS: The pre-specified analyses included 89 switchers and 98 stayers who had post-baseline measurements needed to assess changes. Least squares mean estimates of 10-year CHD risk decreased more for the switch (from 7.0% to 5.2%) than the stay group (from 7.4% to 6.4%) (p = 0.0429). The odds ratio for having metabolic syndrome (stay vs. switch) at the last observation was 1.748 (95% CI 0.919, 3.324, p = 0.0885). CONCLUSION: Switching from olanzapine, quetiapine, or risperidone to aripiprazole was associated with larger reductions in predicted 10-year risk of CHD than the behavioral program alone. The advantage of switching on metabolic syndrome was not statistically significant. The benefits of switching must be balanced against its risks, which in this study included more discontinuations of the study treatment but no significant increase in symptoms or hospitalizations.
|
Authors | T Scott Stroup, Matthew J Byerly, Henry A Nasrallah, Neepa Ray, Ahsan Y Khan, J Steven Lamberti, Ira D Glick, Richard M Steinbook, Joseph P McEvoy, Robert M Hamer |
Journal | Schizophrenia research
(Schizophr Res)
Vol. 146
Issue 1-3
Pg. 190-5
(May 2013)
ISSN: 1573-2509 [Electronic] Netherlands |
PMID | 23434503
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2013 Elsevier B.V. All rights reserved. |
Chemical References |
- Antipsychotic Agents
- Dibenzothiazepines
- Piperazines
- Quinolones
- Benzodiazepines
- Quetiapine Fumarate
- Aripiprazole
- Risperidone
- Olanzapine
|
Topics |
- Adult
- Antipsychotic Agents
(adverse effects)
- Aripiprazole
- Benzodiazepines
(adverse effects)
- Coronary Artery Disease
(chemically induced)
- Dibenzothiazepines
(adverse effects)
- Drug Substitution
(adverse effects)
- Female
- Humans
- Longitudinal Studies
- Male
- Metabolic Syndrome
(chemically induced)
- Middle Aged
- Multicenter Studies as Topic
- Odds Ratio
- Olanzapine
- Piperazines
(adverse effects)
- Quetiapine Fumarate
- Quinolones
(adverse effects)
- Risperidone
(adverse effects)
|