Abstract | UNLABELLED: WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Antichollnergic agents are anticipated to diminish storage symptoms, as well as nocturia. Nevertheless, the effect of this treatment on polyuria related to nocturia is not clear. By subgroup analysis of the data set from a phase III clinical trial of antimuscarinic agent for OAB patients in Japan, imidafenacin was found to improve nocturia with a reduction in nocturnal polyuria. This study adds the effects and underlying mechanism of antimuscarinic agents decreasing urine production through inhibition of C-fibre in the bladder of water-leaded rats. OBJECTIVE: To evaluate the effects and underlying mechanisms of antimuscarinic agents used to decrease in urine production in water-loaded rats. SUBJECTS AND METHODS: RESULTS: Urine production increased and reached its maximum 2 h after 15 mL saline injection. Imidafenacin and tolterodine decreased urine production in water-loaded rats, but ADH, ALD, ANP and BNP levels were not different between imidafenacin-treated and vehicle-treated rats. The inhibitory effect on urine production was not found in RTX-treated rats. Atropine did not reduce urine production. CONCLUSION:
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Authors | Nozomu Watanabe, Hironobu Akino, Tetsuyuki Kurokawa, Minekatu Taga, Ryusei Yokokawa, Kazuya Tanase, Keiko Nagase, Osamu Yokoyama |
Journal | BJU international
(BJU Int)
Vol. 112
Issue 1
Pg. 131-6
(Jul 2013)
ISSN: 1464-410X [Electronic] England |
PMID | 23432937
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2013 BJU International. |
Chemical References |
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Topics |
- Animals
- Disease Models, Animal
- Female
- Muscarinic Antagonists
(pharmacology)
- Nerve Fibers, Unmyelinated
(drug effects)
- Nocturia
(drug therapy, physiopathology)
- Polyuria
(drug therapy, physiopathology)
- Rats
- Rats, Sprague-Dawley
- Urinary Bladder
(drug effects, innervation)
- Urodynamics
(drug effects)
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