Abstract |
A 19-year old Thai male presented to the hospital with fever, acute hemolysis, pallor and jaundice without hepatosplenomegaly. On admission his hematocrit was 17.4% and a blood smear showed moderate hypochromia with mild anisopoikilocytosis. Hemoglobin (Hb) electrophoresis revealed Hb A2ABart's Hb H with an abnormal band, which on PCR proved to be Hb Pyrgos (beta83, glycine --> aspartic acid). The patient inherited beta(Pyrgos) globin from his mother and alpha-thalassemia-1 from his father. He was diagnosed as having Hb H ( alpha-thalassemia-1/alpha-thalssemia-2) heterozygous Hb Pyrgos. He was treated with a transfusion of packed red blood cells. During follow-up his hematocrits ranged from 31 to 34%. The Hb Pyrgos did not add any deleterious effect to his Hb H disease.
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Authors | Somchai Insiripong, Varangnuch Jitpakdeebodin, Yupin Jopang, Supan Fucharoen |
Journal | The Southeast Asian journal of tropical medicine and public health
(Southeast Asian J Trop Med Public Health)
Vol. 43
Issue 5
Pg. 1258-61
(Sep 2012)
ISSN: 0125-1562 [Print] Thailand |
PMID | 23431835
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Hemoglobins
- Hemoglobins, Abnormal
- hemoglobin Pyrgos
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Topics |
- Adult
- Diagnosis, Differential
- Hematocrit
- Hemoglobins
- Hemoglobins, Abnormal
(genetics)
- Heterozygote
- Humans
- Male
- Thailand
- alpha-Thalassemia
(blood, diagnosis, genetics)
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