HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hemoglobin Pyrgos with hemoglobin H disease: new triple heterozygosity.

Abstract
A 19-year old Thai male presented to the hospital with fever, acute hemolysis, pallor and jaundice without hepatosplenomegaly. On admission his hematocrit was 17.4% and a blood smear showed moderate hypochromia with mild anisopoikilocytosis. Hemoglobin (Hb) electrophoresis revealed Hb A2ABart's Hb H with an abnormal band, which on PCR proved to be Hb Pyrgos (beta83, glycine --> aspartic acid). The patient inherited beta(Pyrgos) globin from his mother and alpha-thalassemia-1 from his father. He was diagnosed as having Hb H (alpha-thalassemia-1/alpha-thalssemia-2) heterozygous Hb Pyrgos. He was treated with a transfusion of packed red blood cells. During follow-up his hematocrits ranged from 31 to 34%. The Hb Pyrgos did not add any deleterious effect to his Hb H disease.
AuthorsSomchai Insiripong, Varangnuch Jitpakdeebodin, Yupin Jopang, Supan Fucharoen
JournalThe Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 43 Issue 5 Pg. 1258-61 (Sep 2012) ISSN: 0125-1562 [Print] Thailand
PMID23431835 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Hemoglobins
  • Hemoglobins, Abnormal
  • hemoglobin Pyrgos
Topics
  • Adult
  • Diagnosis, Differential
  • Hematocrit
  • Hemoglobins
  • Hemoglobins, Abnormal (genetics)
  • Heterozygote
  • Humans
  • Male
  • Thailand
  • alpha-Thalassemia (blood, diagnosis, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: