Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia.

Abstract

Hypertriglyceridaemia is an established cause of acute pancreatitis and responds to insulin therapy in addition to lipid lowering medication. We report a case of severe hypertriglycaeridemia of 149 mmol/L in a 36-year-old man with type 2 diabetes who presented to the surgical ward with abdominal pain due to pancreatitis and developed acute cholestasis, jaundice and eruptive xanthomata. His triglycerides improved to 3.8 mmol/L with sliding scale insulin within two weeks of in-hospital stay. However, his total cholesterol remained raised at 23.7 mmol/L. The lipoprotein electrophoresis confirmed the presence of lipoprotein X associated with bile obstruction, which contributed to an increase in total cholesterol. The total cholesterol normalized on improvement of his cholestasis.

• Authors: Karolina M Stepien, Hrushikesh Divyateja, Farhan Ahmed, Peter Prinsloo, Pankaj Gupta
• Journal: Annals of clinical biochemistry (Ann Clin Biochem) Vol. 50 Issue Pt 2 Pg. 173-5 (Mar 2013) ISSN: 1758-1001 [Electronic] England
• PMID: 23431481 (Publication Type: Case Reports, Journal Article)

Chemical References

• Lipoprotein-X

Topics

• Adult
• Cholestasis (blood, complications, therapy)
• Diabetes Mellitus, Type 2 (complications)
• Humans
• Hypertriglyceridemia (complications)
• Lipoprotein-X (blood)
• Male