Abstract | BACKGROUND: AIMS: To examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype. METHOD: In 401 general population twins, four functional polymorphisms were examined in models of psychosis and cortisol, and followed up in models of psychosis in three samples at different familial liability (175 controls, 200 unaffected siblings and 195 patients with a psychotic disorder). RESULTS: The most consistent finding was an interaction between childhood trauma and rs9296158/rs4713916 on psychotic symptoms and cortisol in the twin sample, combined with a directionally similar interaction in siblings (rs4713916) and patients (rs9296158), A-allele carriers at both polymorphisms being most vulnerable to trauma. CONCLUSIONS:
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Authors | Dina Collip, Inez Myin-Germeys, Marieke Wichers, Nele Jacobs, Catherine Derom, Evert Thiery, Tineke Lataster, Claudia Simons, Philippe Delespaul, Machteld Marcelis, Jim van Os, Ruud van Winkel |
Journal | The British journal of psychiatry : the journal of mental science
(Br J Psychiatry)
Vol. 202
Issue 4
Pg. 261-8
(Apr 2013)
ISSN: 1472-1465 [Electronic] England |
PMID | 23429203
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Twin Study)
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Chemical References |
- Tacrolimus Binding Proteins
- tacrolimus binding protein 5
- Hydrocortisone
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Topics |
- Adolescent
- Adult
- Case-Control Studies
- Female
- Gene-Environment Interaction
- Genetic Predisposition to Disease
(genetics)
- Humans
- Hydrocortisone
(metabolism)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
(genetics)
- Psychotic Disorders
(complications, genetics, metabolism)
- Saliva
(metabolism)
- Siblings
(psychology)
- Tacrolimus Binding Proteins
(genetics)
- Wounds and Injuries
(complications, psychology)
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