Paraoxonase 1 and arylesterase levels in children with familial Mediterranean fever.

Abstract

BACKGROUND:

The pathogenesis of Familial Mediterranean Fever (FMF) is not clearly elucidated. It emerges as a result of triggering of the several environmental factors at the people who are genetically vulnerable.

OBJECTIVES:

To evaluate the anti-oxidant enzymes at the remission period of familial mediterranean fever (FMF).

MATERIALS AND METHODS:

Study group is consisted of 80 patients between the age of 2 and 16 years old who are routinely followed up. The control group is consisted of 80 healthy children whose physical examination is normal, and whose demographic findings are similar to the study group. Paraoxonase 1 (PON1) and arylesterase (ARE) levels are measured at both study and control group.

RESULTS:

The difference between the levels of ARE and PON1 are statistically significant between the FMF and control group (p = 0.007, p = 0.001). According to the weight scoring, ARE and PON1 levels of light cases are higher versus the levels of moderate cases (p < 0.01).

CONCLUSIONS:

Endogenous anti-oxidants Paraoxonase 1 and arylesterase levels are important in evaluating the inflammation at the remission period of FMF.

• Authors: C Kosan, A Cayir, M I Turan, S Ustebay
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 17 Issue 3 Pg. 375-8 (Feb 2013) ISSN: 1128-3602 [Print] Italy
• PMID: 23426541 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Carboxylic Ester Hydrolases
• arylesterase
• Aryldialkylphosphatase
• PON1 protein, human

Topics

• Adolescent
• Antioxidants (metabolism)
• Aryldialkylphosphatase (metabolism)
• Carboxylic Ester Hydrolases (metabolism)
• Case-Control Studies
• Child
• Child, Preschool
• Familial Mediterranean Fever (physiopathology)
• Female
• Humans
• Male
• Oxidative Stress
• Severity of Illness Index