Abstract | OBJECTIVE: BACKGROUND: The potential benefits of the use of DAPT beyond a 12-month period in patients receiving DES have not been established clearly. Moreover, it is also unclear whether the optimal duration of DAPT is similar for all DES types. METHODS: RESULTS: A total of 1870 event-free patients on DAPT at 12 months were identified. The average follow-up was 28.2±7.4 months. The primary outcomes were similar between the two groups (4.1% 12-month DAPT vs. 1.9% >12-month DAPT; P=0.090). Incidences of death, MI, stroke, and target vessel revascularization did not differ significantly between the two groups. Subgroup analysis showed that in the patients with hypertension, >12-month DAPT significantly reduced the occurrence of death/MI/ stroke compared with that in the 12-month DAPT group (P=0.04). In patients implanted with SES, the primary outcome was significantly lower with the >12-month DAPT group (5.2% 12-month DAPT vs. 1.6% >12-month DAPT; P=0.016), whereas in patients with ZES, the primary outcome was comparable between the two groups (2.3% 12-month DAPT vs. 2.0% >12-month DAPT; P=0.99). CONCLUSION: In our study, for all patients, >12-month DAPT in patients who had received DES was not significantly more effective than 12-month DAPT in reducing the rate of death/MI/ stroke. Our findings, that patients who received SES benefit from >12-month DAPT whereas extended use of DAPT was not significantly more effective in those implanted with ZES, implied that the optimal duration of DAPT was different depending on different types of DES.
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Authors | Xianpeng Yu, Fang Chen, Jiqiang He, Yuechun Gao, Changyan Wu, Yawei Luo, Xiaoling Zhang, Yuchen Zhang, Xuejun Ren, Shuzheng Lv |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 24
Issue 3
Pg. 217-23
(May 2013)
ISSN: 1473-5830 [Electronic] England |
PMID | 23425771
(Publication Type: Journal Article)
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Chemical References |
- Cardiovascular Agents
- Platelet Aggregation Inhibitors
- Clopidogrel
- zotarolimus
- Ticlopidine
- Aspirin
- Sirolimus
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Topics |
- Aged
- Aspirin
(administration & dosage)
- Cardiovascular Agents
(administration & dosage)
- Chi-Square Distribution
- Clopidogrel
- Coronary Artery Disease
(mortality, therapy)
- Disease-Free Survival
- Drug Administration Schedule
- Drug Therapy, Combination
- Drug-Eluting Stents
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multivariate Analysis
- Myocardial Infarction
(etiology, mortality)
- Percutaneous Coronary Intervention
(adverse effects, instrumentation, mortality)
- Platelet Aggregation Inhibitors
(administration & dosage)
- Proportional Hazards Models
- Prosthesis Design
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Sirolimus
(administration & dosage, analogs & derivatives)
- Stroke
(etiology, mortality)
- Ticlopidine
(administration & dosage, analogs & derivatives)
- Time Factors
- Treatment Outcome
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