Abstract | OBJECTIVE: METHODS: The lead poisoning mice model was established by drinking water, which contained lead acetate, 60 Kunming male mice were randomly divided into 6 groups: control group. The lead poisoning model group, three lead groups treated by the low, medium and high dose of resveratrol, 10 mice in each. The lead concentration and the content of MDA and activity of SOD, GSH-Px, CAT, and ORAC were measured in liver and kidney tissue and serum. RESULTS: Compared with poisoning model group, The activation of SOD, GSH-Px was increased in liver and kidney tissue of three lead groups treated with resveratrol. The activity of SOD, GSH-Px, CAT and the content of MDA were significantly different among the groups (P < 0.01). The antagonizing dose of resveratrol was 800 - 1 200 mg/kg, it can enhance enzymes activity. CONCLUSION:
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Authors | Fangli Liu, Zhenfei Xue, Nan Zhang, Wen Wang, Canying Chen, Wenjie Li |
Journal | Wei sheng yan jiu = Journal of hygiene research
(Wei Sheng Yan Jiu)
Vol. 41
Issue 6
Pg. 920-4
(Nov 2012)
ISSN: 1000-8020 [Print] China |
PMID | 23424868
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Stilbenes
- Lead
- Malondialdehyde
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Resveratrol
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Topics |
- Animals
- Antioxidants
(metabolism)
- Catalase
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Lead
(toxicity)
- Lipid Peroxidation
(drug effects)
- Male
- Malondialdehyde
(metabolism)
- Mice
- Resveratrol
- Stilbenes
(pharmacology)
- Superoxide Dismutase
(metabolism)
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