HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Difference in clinical target lesion revascularization between a silicon carbide-coated and an uncoated thin strut bare-metal stent: the PRO-Vision study.

AbstractBACKGROUND:
Bare-metal stents trigger a foreign body reaction, resulting in neointima formation and restenosis. Silicon carbide (SiC) coating shields the metal from circulating blood and vessel wall, both potential sources of neointima smooth muscle cells.
METHODS:
We investigated whether SiC-coated stents (PRO-Kinetic) have lower clinical target lesion revascularization (TLR) rates than do uncoated bare-metal stents (Vision). Stents were implanted in 2731 patients during 2 consecutive 18-month periods. Clinical TLR was evaluated at 1 year.
RESULTS:
In the PRO-Kinetic group, TLR was significantly higher (9.0% vs 5.6%; unadjusted odds ratio, 1.61; 95% confidence interval [CI], 1.24-2.08; P < 0.001) compared with the Vision group. After adjustment for postintervention minimal luminal diameter (adjusted odds ratio [AOR], 0.56; 95% CI, 0.42-0.73), total implanted stent length (AOR, 1.01; 95% CI, 1.00-1.02), non-ST-segment elevation myocardial infarction or unstable angina at initial presentation (AOR, 1.89; 95% CI, 1.41-2.54), and triple vessel stenting (AOR, 2.68; 95% CI, 1.02-7.05), the use of PRO-Kinetic stents remained an independent predictor for revascularization (AOR, 1.57; 95% CI, 1.18-2.10; P = 0.002). Because strut thickness is lower in 2.0- to 3.0-mm PRO-Kinetic stents, a subgroup analysis (n = 2382 lesions) was performed. Even in this subgroup, PRO-Kinetic implantation proved an independent predictor of TLR (AOR, 1.62; 95% CI, 1.17-2.23; P = 0.003).
CONCLUSION:
In contrast to theoretical expectations, the SiC-coated PRO-Kinetic stent was associated with greater target lesion revascularization rates at 1 year compared with the uncoated Vision stent.
AuthorsSteven E Haine, Barbara M Cornez, Jimmy M Jacobs, Hielko P Miljoen, Tom R Vandendriessche, Marc J Claeys, Johan M Bosmans, Christiaan J Vrints
JournalThe Canadian journal of cardiology (Can J Cardiol) Vol. 29 Issue 9 Pg. 1090-6 (Sep 2013) ISSN: 1916-7075 [Electronic] England
PMID23422360 (Publication Type: Comparative Study, Journal Article)
CopyrightCopyright © 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Carbon Compounds, Inorganic
  • Coated Materials, Biocompatible
  • Silicon Compounds
  • silicon carbide
Topics
  • Aged
  • Carbon Compounds, Inorganic
  • Coated Materials, Biocompatible
  • Coronary Artery Disease (therapy)
  • Coronary Restenosis
  • Female
  • Humans
  • Male
  • Middle Aged
  • Percutaneous Coronary Intervention (methods)
  • Silicon Compounds
  • Stents
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: