Abstract | BACKGROUND: METHODS: We investigated whether SiC-coated stents (PRO-Kinetic) have lower clinical target lesion revascularization (TLR) rates than do uncoated bare- metal stents (Vision). Stents were implanted in 2731 patients during 2 consecutive 18-month periods. Clinical TLR was evaluated at 1 year. RESULTS: In the PRO-Kinetic group, TLR was significantly higher (9.0% vs 5.6%; unadjusted odds ratio, 1.61; 95% confidence interval [CI], 1.24-2.08; P < 0.001) compared with the Vision group. After adjustment for postintervention minimal luminal diameter (adjusted odds ratio [AOR], 0.56; 95% CI, 0.42-0.73), total implanted stent length (AOR, 1.01; 95% CI, 1.00-1.02), non- ST-segment elevation myocardial infarction or unstable angina at initial presentation (AOR, 1.89; 95% CI, 1.41-2.54), and triple vessel stenting (AOR, 2.68; 95% CI, 1.02-7.05), the use of PRO-Kinetic stents remained an independent predictor for revascularization (AOR, 1.57; 95% CI, 1.18-2.10; P = 0.002). Because strut thickness is lower in 2.0- to 3.0-mm PRO-Kinetic stents, a subgroup analysis (n = 2382 lesions) was performed. Even in this subgroup, PRO-Kinetic implantation proved an independent predictor of TLR (AOR, 1.62; 95% CI, 1.17-2.23; P = 0.003). CONCLUSION: In contrast to theoretical expectations, the SiC-coated PRO-Kinetic stent was associated with greater target lesion revascularization rates at 1 year compared with the uncoated Vision stent.
|
Authors | Steven E Haine, Barbara M Cornez, Jimmy M Jacobs, Hielko P Miljoen, Tom R Vandendriessche, Marc J Claeys, Johan M Bosmans, Christiaan J Vrints |
Journal | The Canadian journal of cardiology
(Can J Cardiol)
Vol. 29
Issue 9
Pg. 1090-6
(Sep 2013)
ISSN: 1916-7075 [Electronic] England |
PMID | 23422360
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright © 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Carbon Compounds, Inorganic
- Coated Materials, Biocompatible
- Silicon Compounds
- silicon carbide
|
Topics |
- Aged
- Carbon Compounds, Inorganic
- Coated Materials, Biocompatible
- Coronary Artery Disease
(therapy)
- Coronary Restenosis
- Female
- Humans
- Male
- Middle Aged
- Percutaneous Coronary Intervention
(methods)
- Silicon Compounds
- Stents
- Treatment Outcome
|