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Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection.

Abstract
A practical high-performance liquid chromatography using a Cosmosil HILIC column and UV detection was developed for determining the concentrations of cytosine arabinoside (Ara-C) and uracil arabinoside (Ara-U), which is a major metabolite of Ara-C, in human plasma. This method was used to determine the plasma concentrations of Ara-C and Ara-U in a patient treated with high-dose Ara-C therapy for end-stage renal failure.
AuthorsMasanobu Uchiyama, Yasushi Takamatsu, Kentaro Ogata, Taichi Matsumoto, Shiro Jimi, Kazuo Tamura, Shuuji Hara
JournalBiomedical chromatography : BMC (Biomed Chromatogr) Vol. 27 Issue 7 Pg. 818-20 (Jul 2013) ISSN: 1099-0801 [Electronic] England
PMID23420764 (Publication Type: Journal Article)
CopyrightCopyright © 2013 John Wiley & Sons, Ltd.
Chemical References
  • Cytarabine
  • Arabinofuranosyluracil
Topics
  • Arabinofuranosyluracil (blood, chemistry)
  • Chromatography, High Pressure Liquid (methods)
  • Cytarabine (blood, chemistry)
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Limit of Detection
  • Linear Models
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Spectrophotometry, Ultraviolet

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