Effect of inhaled inactivated Mycobacterium phlei in children with moderate asthma.

Abstract	Bacillus Calmette-Guérin and other mycobacterial vaccines are important therapeutic methods in a series of chronic inflammatory disorders characterized by Th1/Th2 imbalance in which Th2 type cells and cytokines often increase. However, few studies have investigated whether it can reduce or prevent the symptoms and attacks in children with asthma. This study evaluated the effect of inactivated Mycobacterium phlei inhaled by an atomizing device placed on asthmatic children. In this randomized, single-center, Seretide-controlled study, children aged 4-12 years with newly diagnosed, moderate, persistent asthma were treated with either inhaled inactivated M. phlei or inhaled Seretide patch. The efficacy of inhaled inactivated M. phlei was related with the alleviation of asthma symptoms, improvement of lung function and reduction of bronchial hyper-responsiveness and total serum IgE, which was similar with Seretide. These findings may have important clinical value in confirming inhaled inactivated M. phlei as a new therapeutic method in moderately asthmatic children.
Authors	Moyu Ming, Chaoqian Li, Zhixi Luo, Shengqiu Lv
Journal	Immunotherapy (Immunotherapy) Vol. 5 Issue 2 Pg. 191-7 (Feb 2013) ISSN: 1750-7448 [Electronic] England
PMID	23413910 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Androstadienes Bacterial Vaccines Drug Combinations Fluticasone-Salmeterol Drug Combination Vaccines, Inactivated Immunoglobulin E Albuterol
Topics	Administration, Inhalation Albuterol (administration & dosage, analogs & derivatives, immunology) Androstadienes (administration & dosage, immunology) Asthma (blood, immunology, pathology, therapy) Bacterial Vaccines (administration & dosage, immunology) Child Child, Preschool Drug Combinations Female Fluticasone-Salmeterol Drug Combination Humans Immunoglobulin E (blood, immunology) Immunotherapy (methods) Male Mycobacterium phlei (immunology) Respiratory Function Tests Treatment Outcome Vaccines, Inactivated (administration & dosage, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!