[Granulosa cell tumor of the ovary - analysis of 15 cases in a single institution].

Abstract

The best treatment for recurrent granulosa cell tumor(GCT)is considered to be surgical resection, because the effects of chemotherapy or radiation on GCT are obscure. The common site of recurrence is the pelvic cavity, including the surface of the liver and intestine as tumor-dissemination-patterns. Between June 1988 and June 2011, we treated 15 patients with GCT at our hospital. The median follow-up time was 56(22-286)months. Ten patients were stage I, 3 were stage II, and 2 were stage III. No patients had residual lesions at the primary surgery area. Six patients have recurred, and the median disease free survival(DFS)was 85(15-128)months. Six patients had relapses in the pelvic cavity, 2 in the retroperitneal lymph nodes, and 1 in the upper abdomen. Two patients relapsed more than twice; however, the rapid detection of recurrence and surgical resection have kept all patients alive. Thirteen patients have no evidence of disease(NED), 2 are alive with disease(AWD), and no one has died of the disease(DOD). We suggest that maximal debulking surgery to achieve complete cytoreduction of recurrent GCT is the most important treatment for prolonging survival.

• Authors: Katsuhiko Hiromura, Mayuko Ban, Yoshiaki Maseki, Sayako Ikeda, Kikyou Onishi, Akira Yokoi, Midori Nakayama, Akiko Shinbo, Mioko Hando, Ken Miyazaki, Kana Kihira, Tomoko Ando, Kimio Mizuno, Madoka Furuhashi, Masahiko Fujino, Masafumi Ito
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 2 Pg. 203-7 (Feb 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 23411956 (Publication Type: English Abstract, Journal Article)

Topics

• Adult
• Aged
• Combined Modality Therapy
• Female
• Granulosa Cell Tumor (diagnosis, therapy)
• Humans
• Middle Aged
• Neoplasm Staging
• Prognosis
• Young Adult