The prostaglandin D2 receptor (PTGDR) gene in asthma and allergic diseases.

Abstract

The prostaglandin D2 receptor (PTGDR) gene has been associated to asthma and related phenotypes by linking and association studies. Functional studies involving animal models and other expression studies based on in vitro cell models also point to a possible role of polymorphisms in the promoter region, in the differential binding of transcription factors, and thus in PTGDR expression, which appear to be associated to the development of asthma or of susceptibility to the disease.

• Authors: V García-Solaesa, C Sanz-Lozano, J Padrón-Morales, L Hernández-Hernández, A García-Sánchez, M L Rivera-Reigada, I Dávila-González, F Lorente-Toledano, M Isidoro-García
• Journal: Allergologia et immunopathologia (Allergol Immunopathol (Madr)) 2014 Jan-Feb Vol. 42 Issue 1 Pg. 64-8 ISSN: 1578-1267 [Electronic] Singapore
• PMID: 23410912 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 SEICAP. Published by Elsevier Espana. All rights reserved.

Chemical References

• Receptors, Immunologic
• Receptors, Prostaglandin
• prostaglandin D2 receptor

Topics

• Animals
• Asthma (genetics, immunology)
• Genetic Predisposition to Disease
• Genotype
• Humans
• Hypersensitivity (genetics, immunology)
• Polymorphism, Genetic
• Receptors, Immunologic (genetics)
• Receptors, Prostaglandin (genetics)