Abstract | BACKGROUND: METHODS: We conducted a single-center, randomized, open label, parallel-group study in 74 women using DNG/E2V or LNG/EE, and measured nAPCsr and SHBG levels in every phase of the regimen of DNG/E2V. RESULTS: During the pill cycle SHBG levels did not differ between DNG/E2V users and LNG/EE users. nAPCsr levels were overall slightly lower in DNG/E2V users than in LNG/EE users, mean difference -0.44 (95% CI, -1.04 to 0.17) for day 2, -0.20 (95% CI, -0.76 to 0.37) for day 7, -0.27 (95% CI, -0.81 to 0.28) for day 24 and -0.34 (95% CI, -0.91 to 0.24) for day 26. CONCLUSION: No statistical significant differences in nAPCsr and SHBG levels were found between users of the oral contraceptive containing DNG/E2V and LNG/EE, suggesting a comparable thrombotic risk.
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Authors | M Raps, F Rosendaal, B Ballieux, J Rosing, S Thomassen, F Helmerhorst, H van Vliet |
Journal | Journal of thrombosis and haemostasis : JTH
(J Thromb Haemost)
Vol. 11
Issue 5
Pg. 855-61
(May 2013)
ISSN: 1538-7836 [Electronic] England |
PMID | 23410231
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 International Society on Thrombosis and Haemostasis. |
Chemical References |
- Contraceptives, Oral, Combined
- Sex Hormone-Binding Globulin
- dienogest
- Estradiol
- Nandrolone
|
Topics |
- Activated Protein C Resistance
(blood)
- Adolescent
- Adult
- Contraceptives, Oral, Combined
(administration & dosage)
- Estradiol
(administration & dosage, analogs & derivatives)
- Female
- Humans
- Nandrolone
(administration & dosage, analogs & derivatives)
- Sex Hormone-Binding Globulin
(metabolism)
- Young Adult
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