Perinatal xenohormone exposure impacts sweet preference and submandibular development in male rats.

Abstract

OBJECTIVE:

To determine the effect of perinatal exposure to low doses of genistein and/or vinclozolin on submandibular salivary gland (SSG) development in juvenile and adult male rats and to establish a link with sweet preference.

MATERIAL AND METHODS:

Female rats received orally (1 mg kg(-1) body weight/day) genistein and vinclozolin, alone or in combination, from the first gestational day up to weaning. Sweet preference was assessed at weaning and in adulthood in male offspring; submandibular glands were then collected to study the morphogenesis and mRNA expression of steroid receptors, growth factors and taste related proteins.

RESULTS:

Exposure to genistein and/or vinclozolin resulted in a higher saccharin intake on postnatal day 25 (P < 0.05) linked to a higher number of pro-acinar cells (P < 0.01) and mRNA expression of progesterone receptor, growth factors and gustine (P < 0.01). These increases disappeared in adulthood, but mRNA expressions of sex hormone receptors and growth factors were strongly repressed in all treated groups (P < 0.01).

CONCLUSION:

Our findings confirm that the SSG are target for xenohormones and provide evidence that perinatal exposure to low doses of genistein and/or vinclozolin could simultaneously disrupt not only the salivary gland prepubertal development and sweet intake but also endocrine gene mRNA expression later in life.

• Authors: W Kouidhi, R Bergès, C Tiffon, C Desmetz, M El May, J Auger, Mc Canivenc-Lavier
• Journal: Oral diseases (Oral Dis) Vol. 19 Issue 8 Pg. 812-23 (Nov 2013) ISSN: 1601-0825 [Electronic] Denmark
• PMID: 23410115 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Androgen Antagonists
• Oxazoles
• Phytoestrogens
• Genistein
• Saccharin
• vinclozolin

Topics

• Androgen Antagonists (pharmacology)
• Animals
• Animals, Newborn
• Fetus (drug effects)
• Food Preferences (drug effects)
• Genistein (pharmacology)
• Male
• Oxazoles (pharmacology)
• Phytoestrogens (pharmacology)
• Rats
• Rats, Wistar
• Saccharin
• Submandibular Gland (drug effects, growth & development)
• Taste (drug effects)