Abstract | PURPOSE: METHODS: RESULTS: Stimulation with calcium gluconate resulted in significantly higher and more variable preoperative calcitonin serum levels after 2 (241.2 vs. 104.9 pg/mL; P = 0.018) and 5 min (240.6 vs. 87.4 pg/mL; P = 0.007) than stimulation with pentagastrin. Stimulation with calcium gluconate produced 10-fold ( nodular goiter), 15-fold ( thyroiditis), and 21-fold (thyroid neoplasia other than MTC) calcitonin increases over baseline, as opposed to 5-fold, 10-fold, and 8-fold increases after stimulation with pentagastrin. None of the 43 patients, all of whom reverted to undetectable calcitonin serum levels after thyroidectomy, had immunohistochemical evidence of C-cell disease. Subgroup analyses according to gender and thyroid disease, being limited by the low number of patients in each subgroup, did not yield significant differences. CONCLUSIONS:
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Authors | Kerstin Lorenz, Malik Elwerr, Andreas Machens, Mohammed Abuazab, Hans-Jürgen Holzhausen, Henning Dralle |
Journal | Langenbeck's archives of surgery
(Langenbecks Arch Surg)
Vol. 398
Issue 3
Pg. 403-9
(Mar 2013)
ISSN: 1435-2451 [Electronic] Germany |
PMID | 23408061
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Calcitonin
- Pentagastrin
- Calcium Gluconate
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Topics |
- Analysis of Variance
- Biomarkers, Tumor
(blood)
- Calcitonin
(blood)
- Calcium Gluconate
- Carcinoma, Neuroendocrine
- Cohort Studies
- Databases, Factual
- Female
- Humans
- Male
- Pentagastrin
- Preoperative Care
(methods)
- Retrospective Studies
- Risk Assessment
- Sensitivity and Specificity
- Statistics, Nonparametric
- Stimulation, Chemical
- Thyroid Diseases
(blood, pathology, surgery)
- Thyroid Neoplasms
(blood, pathology, surgery)
- Thyroidectomy
(methods)
- Treatment Outcome
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