Acquired and Heritable Thrombophilia in Indian Patients With Pediatric Deep Venous Thrombosis (DVT).

Abstract

Deep venous thrombosis (DVT) in children is more often associated with underlying pathological conditions than with hereditary thrombophilia. The present study is a retrospective analysis of thrombophilia in 285 pediatric patients with venous thrombosis at different sites. Four common thrombophilia markers, that is protein C, protein S, antithrombin III, and factor V Leiden (FVL) mutation, were analyzed. Thrombosis in hepatic and portal veins was more common in pediatric patients (73%) when compared to other sites (27%). Overall, hereditary thrombophilia accounted for 15.5% of the patients with venous thrombosis. The FVL mutation, which was the major causative factor in Budd-Chiari syndrome and portal vein thrombosis cases in the adult group, was not a major contributing factor in pediatric group, that is, 1.8% of the patients. In conclusion, the risk factors for venous thrombosis vary in different age groups.

• Authors: Navin Pai, Kanjaksha Ghosh, Shrimati Shetty
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 20 Issue 6 Pg. 573-6 (Sep 2014) ISSN: 1938-2723 [Electronic] United States
• PMID: 23406614 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © The Author(s) 2013.

Chemical References

• Biomarkers
• Protein C
• Protein S
• factor V Leiden
• Antithrombin III
• Factor V

Topics

• Adolescent
• Antithrombin III (metabolism)
• Biomarkers (blood)
• Budd-Chiari Syndrome (blood, etiology, genetics)
• Child
• Child, Preschool
• Factor V (genetics, metabolism)
• Female
• Humans
• India
• Infant
• Male
• Mutation
• Protein C (metabolism)
• Protein S (metabolism)
• Thrombophilia (blood, complications, genetics)