Abstract | IMPORTANCE: OBSERVATIONS: A 38-year-old man had acute onset of headache, nausea, vomiting, and confusion. He developed a pancerebellar syndrome during the ensuing week. Extensive studies did not reveal any tumor. Cerebrospinal fluid analysis showed a white blood cell count of 60/μL (to convert to ×109 per liter, multiply by 0.001). Brain magnetic resonance imaging findings were normal. For 2 years, the patient was treated with intravenous immunoglobulins and steroids, with partial improvement of the cerebellar ataxia. The patient was negative for onconeural (Hu, Yo, Ri, CV2, Tr, amphiphysin, and Ma2), glutamic acid decarboxylase, and mGluR1 antibodies. Immunohistochemistry on rat brain revealed immunostaining of the cerebellar molecular layer. Homer-3 antibodies were demonstrated by immunoblot of recombinant Homer-3. The clinical features of this patient and a previously described patient with Homer-3 antibodies are similar to those of patients with mGluR1 antibodies. CONCLUSIONS AND RELEVANCE:
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Authors | Romana Höftberger, Lidia Sabater, Angel Ortega, Josep Dalmau, Francesc Graus |
Journal | JAMA neurology
(JAMA Neurol)
Vol. 70
Issue 4
Pg. 506-9
(Apr 2013)
ISSN: 2168-6157 [Electronic] United States |
PMID | 23400636
(Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Carrier Proteins
- Homer Scaffolding Proteins
- Receptors, Metabotropic Glutamate
- metabotropic glutamate receptor type 1
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Topics |
- Adult
- Autoantibodies
(cerebrospinal fluid)
- Carrier Proteins
(immunology)
- Cerebellum
(pathology)
- Encephalitis
(cerebrospinal fluid, complications, pathology)
- Homer Scaffolding Proteins
- Humans
- Magnetic Resonance Imaging
- Male
- Receptors, Metabotropic Glutamate
(immunology)
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