Abstract | UNLABELLED: Infectious complications and their consequences are still key issues in rectal cancer surgery. Currently, intravenous antibiotic administration is a recognized method for lowering the rate of these complications. The aim of the study was to assess the efficacy of complementary application of a gentamicin-impregnated sponge in the perineal wound or in the vicinity of intestinal anastomosis after abdominoperineal resection or low anterior resection. MATERIAL AND METHODS: 112 patients with primary rectal cancer were enrolled in this study. 42 patients were treated with a gentamicin sponge and drainage (group A) and 70 individuals were treated with drainage alone (group B). In the aforementioned groups a routine short-term regimen of antibiotic prophylaxis was used. We applied gentamicin-impregnated sponges in 27 patients in whom anterior resection was performed and in 15 patients from the abdominoperineal resection group (64% and 36%, respectively). In the control group, 44 anterior resections and 26 abdominoperineal resections were carried out (63% and 37%, respectively). RESULTS: We did not observe statistically significant differences in the incidence of suppurative complications (intraabdominal abscess, perineal wound infection): 4 cases (9.52%) in group A and 9 (12.58%) in group B and anastomotic leakage with clinical manifestation after low anterior resection: 1 case (3.7%) in group A and 2 (4.5%) in group B. Postoperative fever of unknown origin was noted more often in group B: 23 patients (32.8%) versus 10 patients (23.8%) in group A and this difference was statistically significant (p<0.05). Hospitalization after surgery was also significantly longer in group B (9-37 days, median 11 days) as compared with group A (8-26 days, median 13 days) (p<0.05). CONCLUSIONS:
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Authors | Zbigniew Morawiec, Mariusz Pawlak, Agnieszka Kołacińska, Adam Dziki |
Journal | Polski przeglad chirurgiczny
(Pol Przegl Chir)
Vol. 84
Issue 12
Pg. 613-7
(Dec 2012)
ISSN: 2299-2847 [Electronic] Poland |
PMID | 23399627
(Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Gentamicins
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Topics |
- Administration, Topical
- Adult
- Aged
- Aged, 80 and over
- Anastomosis, Surgical
(methods)
- Anti-Bacterial Agents
(administration & dosage)
- Digestive System Surgical Procedures
(adverse effects, methods)
- Drainage
- Female
- Fever of Unknown Origin
(epidemiology, etiology)
- Gentamicins
(administration & dosage)
- Humans
- Incidence
- Intraoperative Care
(methods)
- Length of Stay
(statistics & numerical data)
- Male
- Middle Aged
- Rectal Neoplasms
(surgery)
- Surgical Sponges
- Surgical Wound Infection
(epidemiology, etiology, prevention & control)
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