Abstract | BACKGROUND: OBJECTIVE: We sought to assess the efficacy of MMS for the treatment of EMPD. METHODS: A comprehensive systematic review and individual patient data meta-analysis was performed including all available clinical studies and case reports with 5 or more subjects describing the use of MMS for EMPD. RESULTS: Eight studies were identified and included in the current review: 3 retrospective studies and 5 case series. In all, 81 patients with 90 cases of MMS were included from these 8 studies. The overall recurrence rate for EMPD after MMS was 12.2% correlating with an estimated 5-year tumor-free rate of 83.6% by using Kaplan-Meier curve analysis. The treatment of EMPD with MMS resulted in significantly lower recurrence rates than wide local excision in this meta-analysis of 3 observational studies with comparators (odds ratio 0.20; 95% confidence interval 0.05-0.81). LIMITATIONS: Limitations include lack of controlled trials, small sample sizes in the included studies, and publication bias. CONCLUSION: The current evidence supports the efficacy of MMS in the treatment of EMPD. Further controlled clinical trials are needed.
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Authors | Jung Min Bae, Yoon Young Choi, Heesu Kim, Byung Ho Oh, Mi Ryung Roh, KyoungAe Nam, Kee Yang Chung |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 68
Issue 4
Pg. 632-637
(Apr 2013)
ISSN: 1097-6787 [Electronic] United States |
PMID | 23399462
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Topics |
- Humans
- Mohs Surgery
- Paget Disease, Extramammary
(surgery)
- Treatment Outcome
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