Abstract |
This study investigated whether killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen ( HLA)-C alleles, receptors and ligands of natural killer cells are associated with the development of human papillomavirus (HPV)-related cervical disease in Korean women. Blood samples from 132 women with HPV-related cervical disease and 159 women without HPV infection were collected for genotyping of KIR genes and HLA-C alleles. Although no relationship was found between KIR genes and HPV-related cervical disease, a significant relationship was found between HLA-C alleles as ligands of KIR and HPV-related cervical disease. Women with HPV-related cervical disease were found to be significantly more likely to carry HLA-C*0303, particularly those with HPV 16 or 18 infection, and less likely to carry HLA-C*01 compared to women without HPV infection. HLA-C*0303 was found to confer susceptibility to HPV-related cervical disease, whereas HLA-C*01 was found to confer a protective effect against HPV-related cervical disease.
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Authors | M J Song, C W Lee, J H Kim, S J Lee, C J Kim, S Y Hur, T C Park, T G Kim, J S Park |
Journal | Tissue antigens
(Tissue Antigens)
Vol. 81
Issue 3
Pg. 164-70
(Mar 2013)
ISSN: 1399-0039 [Electronic] England |
PMID | 23398510
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons A/S. |
Chemical References |
- HLA-C Antigens
- Receptors, KIR
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Topics |
- Adult
- Aged
- Alleles
- Asian People
(genetics)
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- HLA-C Antigens
(genetics, immunology)
- Humans
- Middle Aged
- Papillomavirus Infections
(genetics, immunology)
- Receptors, KIR
(genetics)
- Republic of Korea
- Risk Factors
- Uterine Cervical Neoplasms
(genetics, immunology, virology)
- Young Adult
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