Modified dipeptide-based nanoparticles: vehicles for targeted tumor drug delivery.

Abstract

AIM:

Different nanoparticles have been investigated to deliver chemotherapeutic agents, but complex synthesis procedures and biocompatibility issues raise concerns in developing them for safe human usage. The aim of this work is to develop α,β-dehydrophenylalanine-containing, self-assembled, amphipathic dipeptide nanoparticles for tumor-targeted drug delivery and therapy.

MATERIAL & METHODS:

Solution-phase peptide synthesis was used to synthesize dipeptides. Nanoparticles were prepared by molecular self-assembly. A tumor distribution study was carried out using a radiolabeling method. Tumor regression studies were carried out in murine ascitic tumors in BALB/c mice and breast tumor xenografts in in nonobese diabetic/severe combined immunodeficiency mice.

RESULTS:

Arg-α,β-dehydrophenylalanine formed self-assembled nanoparticles that could be easily derivatized with folic acid. Folic acid-derivatized nanoparticles showed enhanced cellular uptake and, when loaded with doxorubicin, showed enhanced tumor regression compared with underivatized nanoparticles or native drug, without any adverse side effects, both in vitro and in vivo.

• Authors: Jiban J Panda, Ankur Kaul, Santosh Kumar, Shadab Alam, Anil K Mishra, Gopal C Kundu, Virander S Chauhan
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 8 Issue 12 Pg. 1927-42 (Dec 2013) ISSN: 1748-6963 [Electronic] England
• PMID: 23398497 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Dipeptides
• Phenylalanine
• Doxorubicin
• Folic Acid

Topics

• Animals
• Antibiotics, Antineoplastic (administration & dosage, pharmacokinetics)
• Cell Line, Tumor
• Dipeptides (chemistry, metabolism)
• Doxorubicin (administration & dosage, pharmacokinetics)
• Drug Delivery Systems
• Female
• Folic Acid (chemistry, metabolism)
• Humans
• Mice
• Mice, Inbred BALB C
• Nanoparticles (chemistry, metabolism)
• Neoplasms (drug therapy, pathology)
• Phenylalanine (analogs & derivatives, metabolism)