Abstract | OBJECT: The aim of this study was to answer whether overall survival and progression-free survival are increased in patients with anaplastic glioma who are treated with radiotherapy plus chemotherapy as compared with those who treated with radiotherapy alone. METHODS: Searches of the MEDLINE (PubMed), Embase and Cochrane Library from January 2001 to May 2012 for relevant trials were undertaken. Selected studies based on the following criteria: First, only randomized clinical trial of adjuvant radiotherapy plus chemotherapy versus radiotherapy alone was permitted. Second, overall survival and/or progression-free survival was compared with patients in the studies. Third, cases were medically confirmed of anaplastic glioma. RESULTS: 4 randomized clinical trials were found eligible for this article (involving a total of 963 patients). The meta-analysis showed a significant increase in overall survival in patients treated with radiotherapy plus chemotherapy (HR = 0.84, 95 % CI 0.72-0.98, P = 0.031). CONCLUSIONS:
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Authors | Lei Zhang, Xiaojun Wu, Tao Xu, Chun Luo, Jun Qian, Yicheng Lu |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 139
Issue 5
Pg. 719-26
(May 2013)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 23397358
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Brain Neoplasms
(drug therapy, radiotherapy, therapy)
- Combined Modality Therapy
- Glioma
(drug therapy, radiotherapy, therapy)
- Humans
- Odds Ratio
- Publication Bias
- Radiotherapy
(adverse effects)
- Survival Analysis
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