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Sodium fluoride lacks mitogenic activity for fetal human bone cells in vitro.

Abstract
Sodium fluoride has been shown to be effective therapy for some patients with vertebral osteoporosis. Data from histomorphometric studies in patients and animals suggest that at least part of this effect may be a consequence of a proliferative effect of fluoride, either direct or indirect, on the osteoblast or on an osteoblastic precursor cell. Experiments with osteoblastic cells derived from embryonic chick calvaria have demonstrated a mitogenic effect of fluoride. The present study examined whether fluoride affects in a similar way fetal human bone cells derived from femur or calvaria. Under a variety of culture conditions, including medium supplemented with serum and in serum-free medium, fluoride did not alter the proliferative rate of human bone cells as measured by thymidine incorporation and direct cell counting.
AuthorsJ B Kopp, P G Robey
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (J Bone Miner Res) Vol. 5 Suppl 1 Pg. S137-41 (Mar 1990) ISSN: 0884-0431 [Print] United States
PMID2339623 (Publication Type: Journal Article)
Chemical References
  • Mitogens
  • Sodium Fluoride
  • Thymidine
Topics
  • Bone and Bones (cytology, drug effects, embryology)
  • Cell Division (drug effects)
  • Cells, Cultured
  • Humans
  • Mitogens
  • Osteoblasts (drug effects)
  • Phenotype
  • Sodium Fluoride (pharmacology)
  • Thymidine (metabolism)

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