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Neuroparalytic keratitis and capsaicin.

Abstract
Subcutaneous injection of 50 mg/kg capsaicin to newborn rats resulted in a marked decrease of heat pain sensitivity and neurogenic inflammation. There was, however, no significant difference between capsaicin-pretreated and control rats in the severity of neuroparalytic keratitis after surgical deafferentation of the eye. Retrobulbar injection of 100 microliters of 0.5% capsaicin produced keratitis-like corneal changes. These changes were not prevented by previous pretreatment with a total subcutaneous dose of 200 mg/kg capsaicin. The findings indicate that corneal changes after deafferentation are not due to excessive release of substance P and other neuropeptides from the degenerating afferent fibres.
AuthorsG G Knyazev, G B Knyazeva, A F Nikiforov
JournalActa physiologica Hungarica (Acta Physiol Hung) Vol. 75 Issue 1 Pg. 29-34 ( 1990) ISSN: 0231-424X [Print] Hungary
PMID2339605 (Publication Type: Journal Article)
Chemical References
  • Neuropeptides
  • Evans Blue
  • Capsaicin
Topics
  • Animals
  • Aqueous Humor (metabolism)
  • Capillary Permeability (drug effects)
  • Capsaicin (pharmacology)
  • Denervation
  • Evans Blue
  • Keratitis (etiology, physiopathology)
  • Male
  • Neuropeptides (physiology)
  • Ophthalmic Nerve (physiology, surgery)
  • Pain (physiopathology)
  • Rats
  • Rats, Inbred Strains

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