Abstract |
Subcutaneous injection of 50 mg/kg capsaicin to newborn rats resulted in a marked decrease of heat pain sensitivity and neurogenic inflammation. There was, however, no significant difference between capsaicin-pretreated and control rats in the severity of neuroparalytic keratitis after surgical deafferentation of the eye. Retrobulbar injection of 100 microliters of 0.5% capsaicin produced keratitis-like corneal changes. These changes were not prevented by previous pretreatment with a total subcutaneous dose of 200 mg/kg capsaicin. The findings indicate that corneal changes after deafferentation are not due to excessive release of substance P and other neuropeptides from the degenerating afferent fibres.
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Authors | G G Knyazev, G B Knyazeva, A F Nikiforov |
Journal | Acta physiologica Hungarica
(Acta Physiol Hung)
Vol. 75
Issue 1
Pg. 29-34
( 1990)
ISSN: 0231-424X [Print] Hungary |
PMID | 2339605
(Publication Type: Journal Article)
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Chemical References |
- Neuropeptides
- Evans Blue
- Capsaicin
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Topics |
- Animals
- Aqueous Humor
(metabolism)
- Capillary Permeability
(drug effects)
- Capsaicin
(pharmacology)
- Denervation
- Evans Blue
- Keratitis
(etiology, physiopathology)
- Male
- Neuropeptides
(physiology)
- Ophthalmic Nerve
(physiology, surgery)
- Pain
(physiopathology)
- Rats
- Rats, Inbred Strains
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