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[Percutaneous left atrial appendage closure after resolution of left atrial appendage thrombi with dabigatran].

Abstract
The "gold standard" of the prevention of atrial fibrillation related thromboembolic events is anticoagulation therapy with oral vitamin K antagonists. A certain proportion of high-risk patients with atrial fibrillation are not receiving effective antithrombotic therapy because of problems associated with its use. Resolution of subsequent left atrial appendage thrombi is quite a great challenge in patients who are not tolerating "standard" antithrombotic drugs. According to the knowledge of the authors, this is the first report of a patient with non-valvular persistent atrial fibrillation and high stroke risk, who was intolerant to "standard" anticoagulant therapy and had persistent left atrial appendage thrombi following the use of a wide variety of "standard" anticoagulants. Successful resolution of left atrial appendage thrombi with dabigatran and successful percutaneous left atrial appendage closure were performed in this case.
AuthorsZsuzsanna Kis, Csaba Földesi, Mátyás Pál, Zoltán Som, Andrea Csillik, Pál Abrahám, András Temesvári, Géza Fontos, András Szatmári, Péter Andréka, Attila Kardos
JournalOrvosi hetilap (Orv Hetil) Vol. 154 Issue 7 Pg. 262-5 (Feb 17 2013) ISSN: 0030-6002 [Print] Hungary
Vernacular TitlePercutan bal pitvari fülcsezárás dabigatrannal való fülcsethrombus feloldását követÅ‘en.
PMID23395790 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anticoagulants
  • Antithrombins
  • Benzimidazoles
  • Heparin, Low-Molecular-Weight
  • beta-Alanine
  • Dabigatran
Topics
  • Anticoagulants (administration & dosage)
  • Antithrombins (therapeutic use)
  • Atherectomy
  • Atrial Appendage (diagnostic imaging, pathology)
  • Atrial Fibrillation (diagnostic imaging, therapy)
  • Benzimidazoles (therapeutic use)
  • Comorbidity
  • Dabigatran
  • Echocardiography, Transesophageal
  • Female
  • Heparin, Low-Molecular-Weight (administration & dosage)
  • Humans
  • Middle Aged
  • Obesity, Morbid (complications)
  • Risk Factors
  • Stroke (prevention & control)
  • Thrombosis (diagnostic imaging, drug therapy)
  • Treatment Outcome
  • beta-Alanine (analogs & derivatives, therapeutic use)

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