Abstract | BACKGROUND: PATIENTS AND METHODS: The expression of HAI-1 was evaluated by immunohistochemistry (IHC) of samples from 51 patients with negative prostate biopsies and 75 patients with untreated prostate cancer. Furthermore, the expression of HAI-1 was evaluated in 24 patients with castration-resistant prostate cancer (CRPC), and the relationship between HAI-1 expression and the prostate-specific antigen (PSA) progression-free rate was investigated. RESULTS: Expression of HAI-1 by IHC in patients with prostate cancer was significantly higher than in those with negative prostate biopsy. CRPC exhibited significantly lower HAI-1 expression than untreated metastatic prostate cancer. The PSA progression-free rate was worse in patients without HAI-1 expression than in those with positive HAI-1 expression. CONCLUSION: It is suggested that HAI-1 may play an important role in the pathogenesis of CRPC.
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Authors | Kenji Yasuda, Akira Komiya, Akihiko Watanabe, Akihiro Morii, Takeshi Oya, Osamu Nagakawa, Yasuyoshi Fujiuchi, Hideki Fuse |
Journal | Anticancer research
(Anticancer Res)
Vol. 33
Issue 2
Pg. 575-81
(Feb 2013)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 23393351
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgen Antagonists
- Biomarkers, Tumor
- Proteinase Inhibitory Proteins, Secretory
- SPINT1 protein, human
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Topics |
- Aged
- Androgen Antagonists
(therapeutic use)
- Biomarkers, Tumor
(analysis)
- Disease Progression
- Disease-Free Survival
- Drug Resistance, Neoplasm
(physiology)
- Humans
- Immunohistochemistry
- Male
- Neoplasm Grading
- Neoplasm Staging
- Prostatic Neoplasms
(metabolism, mortality, pathology)
- Proteinase Inhibitory Proteins, Secretory
(biosynthesis)
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