Expression of Hepatocyte growth factor activator inhibitor type-1 (HAI-1) in prostate cancer.

Abstract

BACKGROUND:

Hepatocyte growth factor activator inhibitor type-1 (HAI-1) inhibits hepatocyte growth factor activator and matriptase. In the present study it was investigated whether the expression of HAI-1 is associated with the progression of prostate cancer.

PATIENTS AND METHODS:

The expression of HAI-1 was evaluated by immunohistochemistry (IHC) of samples from 51 patients with negative prostate biopsies and 75 patients with untreated prostate cancer. Furthermore, the expression of HAI-1 was evaluated in 24 patients with castration-resistant prostate cancer (CRPC), and the relationship between HAI-1 expression and the prostate-specific antigen (PSA) progression-free rate was investigated.

RESULTS:

Expression of HAI-1 by IHC in patients with prostate cancer was significantly higher than in those with negative prostate biopsy. CRPC exhibited significantly lower HAI-1 expression than untreated metastatic prostate cancer. The PSA progression-free rate was worse in patients without HAI-1 expression than in those with positive HAI-1 expression.

CONCLUSION:

It is suggested that HAI-1 may play an important role in the pathogenesis of CRPC.

• Authors: Kenji Yasuda, Akira Komiya, Akihiko Watanabe, Akihiro Morii, Takeshi Oya, Osamu Nagakawa, Yasuyoshi Fujiuchi, Hideki Fuse
• Journal: Anticancer research (Anticancer Res) Vol. 33 Issue 2 Pg. 575-81 (Feb 2013) ISSN: 1791-7530 [Electronic] Greece
• PMID: 23393351 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Androgen Antagonists
• Biomarkers, Tumor
• Proteinase Inhibitory Proteins, Secretory
• SPINT1 protein, human

Topics

• Aged
• Androgen Antagonists (therapeutic use)
• Biomarkers, Tumor (analysis)
• Disease Progression
• Disease-Free Survival
• Drug Resistance, Neoplasm (physiology)
• Humans
• Immunohistochemistry
• Male
• Neoplasm Grading
• Neoplasm Staging
• Prostatic Neoplasms (metabolism, mortality, pathology)
• Proteinase Inhibitory Proteins, Secretory (biosynthesis)