Abstract | SIGNIFICANCE: RECENT ADVANCES: CRITICAL ISSUES: It has been found that isoflavone, I3C, and DIM could inhibit cancer development and progression by regulating multiple cellular signaling pathways that are related to oxidative stress and significantly deregulated in cancer. FUTURE DIRECTIONS: The antioxidative and anticancer effects of these natural agents make them strong candidates for chemoprevention and/or therapy against human malignancies. However, more clinical trials are needed to evaluate the effects of isoflavone and DIM for the prevention of cancer development and also for the treatment of cancer either alone or in combination with conventional cancer therapeutics.
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Authors | Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, Fazlul H Sarkar |
Journal | Antioxidants & redox signaling
(Antioxid Redox Signal)
Vol. 19
Issue 2
Pg. 139-50
(Jul 10 2013)
ISSN: 1557-7716 [Electronic] United States |
PMID | 23391445
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Anticarcinogenic Agents
- Antineoplastic Agents
- Antioxidants
- Biological Factors
- Indoles
- Isoflavones
- 3,3'-diindolylmethane
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Topics |
- Animals
- Anticarcinogenic Agents
(pharmacology)
- Antineoplastic Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Biological Factors
(pharmacology)
- Humans
- Indoles
(pharmacology)
- Isoflavones
(pharmacology)
- Neoplasms
(drug therapy, prevention & control)
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