A simple screening test for the detection of erythropoietin antibodies.

Abstract

Antibody-mediated pure red cell aplasia (PRCA) is a rare complication of erythropoietin (EPO) therapy. Identification and demonstration of functional activity of EPO antibodies required to diagnose this condition is difficult and only performed in selected laboratories worldwide. In this article we report a recent cluster of three cases of antibody-mediated PRCA over a 16-month period in a single center associated with EPREX use. We also describe the use of a simple low-cost inhibitor assay that can be used to screen for PRCA in local laboratories.

• Authors: Soma Meran, Alexa Wonnacott, Mat Davies, Richard Ellis, Aled Phillips
• Journal: Clinical nephrology (Clin Nephrol) Vol. 82 Issue 3 Pg. 215-20 (Sep 2014) ISSN: 0301-0430 [Print] Germany
• PMID: 23391321 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Neutralizing
• Biomarkers
• Recombinant Proteins
• Erythropoietin
• Epoetin Alfa

Topics

• Aged
• Aged, 80 and over
• Anemia (blood, diagnosis, drug therapy)
• Antibodies, Neutralizing (blood)
• Biomarkers (blood)
• Calibration
• Epoetin Alfa
• Erythropoietin (adverse effects, immunology)
• Humans
• Male
• Predictive Value of Tests
• Recombinant Proteins (adverse effects, immunology)
• Red-Cell Aplasia, Pure (blood, chemically induced, diagnosis, immunology)
• Reference Standards
• Serologic Tests (standards)