Complex roles of filamin-A mediated cytoskeleton network in cancer progression.

Abstract

Filamin-A (FLNA), also called actin-binding protein 280 (ABP-280), was originally identified as a non-muscle actin binding protein, which organizes filamentous actin into orthogonal networks and stress fibers. Filamin-A also anchors various transmembrane proteins to the actin cytoskeleton and provides a scaffold for a wide range of cytoplasmic and nuclear signaling proteins. Intriguingly, several studies have revealed that filamin-A associates with multiple non-cytoskeletal proteins of diverse function and is involved in several unrelated pathways. Mutations and aberrant expression of filamin-A have been reported in human genetic diseases and several types of cancer. In this review, we discuss the implications of filamin-A in cancer progression, including metastasis and DNA damage response.

• Authors: Jingyin Yue, Steven Huhn, Zhiyuan Shen
• Journal: Cell & bioscience (Cell Biosci) Vol. 3 Issue 1 Pg. 7 (Feb 06 2013) ISSN: 2045-3701 [Print] England
• PMID: 23388158 (Publication Type: Journal Article)