Abstract | BACKGROUND: Carcinogenic products in the exhaled breath of cancer patients are of growing medical interest as they can serve as noninvasive disease markers. Breath analysis can be used as an alternative or complementary diagnostic tool in breast cancer patients who have a different pattern of chemical composition in their breath. This study aims to verify the existence of specific volatile organic compounds (VOCs) in the breath of breast cancer patients. METHODS: RESULTS: The spectrum of VOCs differed significantly within the two groups. Five specific VOCs could be identified as typical discriminatory markers in the breath samples. Four VOCs were elevated in the healthy controls, one specific VOC was found to be elevated in women affected by breast cancer
CONCLUSIONS: This pilot study revealed a specific VOC pattern using gas chromatography in the breath of breast cancer patients. Five specific breast cancer-VOCs were identified. At relatively low cost the identification of VOCs may be used to detect breast cancer.
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Authors | Mandy Mangler, Cornelia Freitag, Malgorzata Lanowska, Oliver Staeck, Achim Schneider, Dorothee Speiser |
Journal | Ginekologia polska
(Ginekol Pol)
Vol. 83
Issue 10
Pg. 730-6
(Oct 2012)
ISSN: 0017-0011 [Print] Poland |
PMID | 23383557
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Aldehydes
- Alkanes
- Benzene Derivatives
- Biomarkers, Tumor
- Esters
- Volatile Organic Compounds
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Topics |
- Adult
- Aged
- Aldehydes
(analysis)
- Alkanes
(analysis)
- Benzene Derivatives
(analysis)
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(diagnosis)
- Breath Tests
(methods)
- Esters
(analysis)
- Female
- Gas Chromatography-Mass Spectrometry
- Humans
- Middle Aged
- Poland
- Predictive Value of Tests
- Reference Standards
- Volatile Organic Compounds
(analysis)
- Women's Health
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