Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study.

Abstract

OBJECTIVE:

Evaluate the efficacy of 0.8% arginine, potassium nitrate and sodium fluoride mouthwashes on dentine hypersensitivity reduction.

METHODS:

Six week randomized, double blinded, two cell, parallel single centre clinical study in the Dominican Republic; subjects were randomized into three treatment groups: mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride in an alcohol-free base (arginine); mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride (potassium nitrate); a control mouthwash containing 0.05% sodium fluoride (negative control). Tactile and air-blast dentine hypersensitivity assessments were conducted at baseline, thirty minutes post rinsing and two, four, and six weeks of twice-daily product use. For treatment group comparisons, ANCOVA and post hoc Tukey's pair-wise comparisons (α=0.05) were done.

RESULTS:

Seventy-five subjects were enrolled; 69 subjects completed the study. There were no differences after thirty minutes of a single use, among the three groups with respect to mean tactile and air blast hypersensitivity scores compared to potassium nitrate and negative control mouthwashes (p<0.05). The arginine group presented a statistically significant improvement in the mean tactile scores compared to potassium nitrate and negative control groups after two, four, and six weeks (p<0.001) of product use; the arginine group showed a statistically significant enhancement in air blast hypersensitivity mean scores compared to potassium nitrate and negative control groups after two (p=0.001), four (p<0.001), and six weeks (p<0.001) of product use.

CONCLUSION:

A mouthwash containing arginine provides a significant and superior reduction in dentine hypersensitivity compared to potassium nitrate and a negative control mouthwash after two weeks.

• Authors: Augusto R Elías Boneta, Rafael M Galán Salás, Luis R Mateo, Bernal Stewart, Sarita Mello, Lia S Arvanitidou, Foti Panagakos, William DeVizio
• Journal: Journal of dentistry (J Dent) Vol. 41 Suppl 1 Pg. S34-41 (Mar 2013) ISSN: 1879-176X [Electronic] England
• PMID: 23380074 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Dentin Desensitizing Agents
• Diphosphates
• Drug Combinations
• Maleates
• Mouthwashes
• Phosphates
• Polyethylenes
• pro-argin
• diphosphoric acid
• Sodium Fluoride
• poly(methyl vinyl ether-co-maleic anhydride)
• Arginine
• Calcium Carbonate
• Fluorides

Topics

• Adult
• Aged
• Air
• Analysis of Variance
• Arginine (chemistry, therapeutic use)
• Calcium Carbonate (chemistry, therapeutic use)
• Chi-Square Distribution
• Dentin
• Dentin Desensitizing Agents (therapeutic use)
• Dentin Sensitivity (drug therapy)
• Diphosphates (therapeutic use)
• Double-Blind Method
• Drug Combinations
• Female
• Fluorides (chemistry, therapeutic use)
• Humans
• Male
• Maleates (therapeutic use)
• Middle Aged
• Mouthwashes (chemistry, therapeutic use)
• Phosphates (chemistry, therapeutic use)
• Polyethylenes (therapeutic use)
• Prospective Studies
• Sodium Fluoride (therapeutic use)
• Touch
• Young Adult